Table 1.

Overview of the role of DEAD box polypeptide 5 (DDX5) in virus infection.

Virus	Viral Binding Protein	Effect of DDX5 on Viral Replication	Ref.
SARS-CoV	nsp13	Enhances virus proliferation	[16]
IBV-CoV	nsp13	Enhances virus proliferation	[16]
HIV-1	Rev	Enhances the Rev-dependent RNA export	[17]
HCV	NS5B	Required for transcription of viral RNA	[18]
JEV	C, NS3 and NS5	Required for viral RNA replication	[19]
PRRSV	nsp9	Required for viral replication	[20]
Influenza virus	NP	Required for viral replication	[21]
EBV	EBNA2	Unknown	[24]
Pestivirus	Npro	Unknown	[25]
Myxoma virus	Unknown	Inhibits viral replication	[22]
HBV	Unknown	Inhibits viral replication	[23]

SARS-CoV: severe acute respiratory syndrome coronavirus; IBV-CoV: infectious bronchitis virus coronavirus; HIV-1: human immunodeficiency virus 1; HBV: hepatitis B virus; HCV: hepatitis C virus; JEV: japanese encephalitis virus; PRRSV: porcine reproductive and respiratory syndrome virus; EBV: Epstein-Barr virus; nsp: nonstructural protein; NP: nucleoprotein; EBNA2: Epstein–Barr virus nuclear antigen 2; N^pro: N-terminal protease.