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. 2018 Mar 26;19(4):984. doi: 10.3390/ijms19040984

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Model of the podosome field. The model illustrates a perspective of the basic structural elements of the podosome field in the pattern of the podosome cluster. The podosome field represents a distinct entity in the plasma membrane and comprises the actin cores, a network of F-actin cables, integrin islets, and the actin flow. The actin flow is generated by Arp2/3-dependent branched actin elongation. Pattern transitions of the podosome field may produce the podosome cluster, the podosome ring, the podosome belt, and the zipper-like structure in osteoclasts.