Table 2.
Differential expression Core analyses of regulated transcripts in the comparisons C57Bl6 vs. alb-SREBP-1a, C57Bl6 vs. alb-SREBP-1a∆P and alb-SREBP-1a vs. alb-SREBP-1a∆P. Examples as listed in text. p-value: p-value for enrichment of pathway molecules in the data set. Complete analyses are given in Tables S3–S5.
| C57Bl6 vs. alb-SREBP-1a | |||||||
| Canonical Pathways | p-Value | Upstream Activator | p-Value | Disease or Tox Function | p-Value | Interaction Network | p-Value |
| FXR/RXR | 6.76 × 10−6 | RORA | 2.67 × 10−18 | hepatic steatosis associated pathways. | 1.60 × 10−7 | ACOX1 | 1.76 × 10−12 |
| PPAR | 1.58 × 10−4 | RORC | 1.98 × 10−13 | liver cholestasis | 1.30 × 10−3 | MAPK7 | 2.93 × 10−12 |
| sirtuin signaling | 2.63 × 10−4 | PPARA | 1.22 × 10−11 | liver hyperplasia/hyperproliferation | 2.76 × 10−3 | ONECUT1 | 3.16 × 10−11 |
| PPARD | 1.16 × 10−8 | liver proliferation | 1.80 × 10−3 | PPARA | 3.33 × 10−9 | ||
| GPD1 | 5.31 × 10−11 | renal damage | 6.15 × 10−4 | ||||
| SLC25A13 | 7.24 × 10−11 | nonalcoholic fatty liver disease | 8.13 × 10−3 | ||||
| HNF4A | 4.59 × 10−6 | ||||||
| C57Bl6 vs. alb-SREBP-1a ΔP | |||||||
| Canonical Pathways | p-Value | Upstream Activator | p-Value | Disease or Tox Function | p-Value | Interaction Network | p-Value |
| methionine degradation | 3.24 × 10−6 | HNF4A | 9.23 × 10−29 | olfactory response | 2.32 × 10−144 | ACOX1 | 2.51 × 10−9 |
| isoleucinedegradation | 3.89 × 10−4 | RORC | 1.56 × 10−9 | olfaction | 1.68 × 10−139 | GRB14 | 6.14 × 10−9 |
| valine degradation | 2.40 × 10−3 | RORA | 7.56 × 10−9 | signal transduction | 4.91 × 10−60 | PPARGC1A | 2.10 × 10−6 |
| cysteine biosynthesis | 9.33 × 10−5 | ONECUT1 | 2.85 × 10−8 | Cell communication | 1.30 × 10−55 | ||
| autophagy | 1.12 × 10−3 | MYC | 4.47 × 10−7 | RNA post-transcriptional modification | 2.08 × 10−6 | ||
| protein ubiquitination | 1.12 × 10−3 | NR1D1 | 1.76 × 10−6 | synthesis of ribonucleoside monophosphate | 7.74 × 10−6 | ||
| sirtuin signaling | 8.51 × 10−3 | ACOX1 | 4.78 × 10−10 | amino acids metabolism | 6.02 × 10−10 | ||
| ceramide biosynthesis | 4.27 × 10−3 | PPARA | 6.16 × 10−6 | oxidation of lipid | 3.08 × 10−6 | ||
| fatty acid β-oxidation | 2.29 × 10−2 | RXRA | 8.74 × 10−4 | oxidation of fatty acids | 8.63 × 10−6 | ||
| fatty acid metabolism | 9.55 × 10−6 | ||||||
| bleeding of liver | 1.55 × 10−3 | ||||||
| compensated cirrhosis | 7.29 × 10−3 | ||||||
| liver degeneration | 7.31 × 10−3 | ||||||
| cholestasis | 8.51 × 10−3 | ||||||
| alb-SREBP-1a vs. alb-SREBP-1aΔP | |||||||
| Canonical Pathways | p-Value | Upstream Activator | p-Value | Disease or Tox Function | p-Value | Interaction Network | p-Value |
| RNA polymerase II complex assembly | 9.33 × 10−5 | HNF4A | 4.34 × 10−13 | olfactory response | 7.51 × 10−123 | NCAM1 | 2.17 × 10−5 |
| protein ubiquitination | 9.12 × 10−4 | RORC | 6.11 × 10−5 | olfaction | 2.92 × 10−120 | ACOX1 | 4.32 × 10−5 |
| sirtuin signaling | 1.02 × 10−2 | RORA | 6.26 × 10−5 | signal transduction | 7.55 × 10−61 | SIRT4 | 1.56 × 10−4 |
| sumoylation | 3.72 × 10−2 | PPARA | 2.13 × 10−4 | cell communication | 1.49 × 10−57 | NR2F1 | 2.55 × 10−4 |
| ACOX1 | 1.71 × 10−5 | RNA post-transcriptional processing | 2.69 × 10−7 | FOXO4 | 4.82 × 10−4 | ||
| RNA transport | 2.66 × 10−6 | FABP1 | 5.98 × 10−4 | ||||
| differentiation processes | 1.78 × 10−5 | ABCB1 | 9.88 × 10−4 | ||||
| clearance of bilirubin | 6.17 × 10−3 | PPARA | 1.17 × 10−3 | ||||
| proliferation of hepatic stellate cells | 4.42 × 10−2 | ||||||
| hepatomegaly | 6.43 × 10−2 | ||||||