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. 2018 Apr 12;19(4):1167. doi: 10.3390/ijms19041167

Figure 1.

Figure 1

Targeting adenosine triphosphate (ATP) and adenosine (ADO): A Yin and Yang of the immune system. ATP and ADO are present in tissues or in the tumor niche at variable concentrations. Shifting the balance between these two metabolites results in inflammation (high ATP concentration) or immunosuppression (high ADO concentration). Both these extremes represent a potentially harmful condition, considering the biological consequences exerted on cells of the immune system.