Figure 3.

Taurine administration partially improved locomotor activity, anxiety and exploration in AS female (Ube3a^m−/p+) mice. Open field assay was carried out at four time points (7, 14, 21 and 30 weeks) on wild type (WT) and Ube3a^m−/p+ mice (both treated (taurine) and untreated (vehicle)) by measuring (a) total distance traveled (m); (b) distance in center square (m) and (c) number of rearings. Analyses were conducted by separating genders (male: left panels; female: right panels). Number of animals per group: male mice (wt + vehicle = 13, wt + taurine = 12, Ube3a^m−/p+ + vehicle = 11, Ube3a^m−/p+ + taurine = 12); female mice (wt + vehicle = 13, wt + taurine = 13, Ube3a^m−/p+ + vehicle = 11, Ube3a^m−/p+ + taurine = 13). Data are shown, for each time point, as media ± SEM. Effect of genotype: * p < 0.05, ** p <0.01, *** p < 0.001; effect of taurine treatment on Ube3a^m−/p+ genotype: ^# p <0.05, ^## p <0.01, ^### p < 0.001.