Figure 4.

Taurine treatment improved learning and memory in AS (Ube3a^m−/p+) mice. Novel object recognition test was carried out at four time points (7, 14, 21 and 30 weeks) on wild type (WT) and Ube3a^m−/p+ mice (both treated (taurine) and untreated (vehicle)). Analyses were conducted by separating genders (male: left panel; female: right panel). Number of animals per group: male mice (wt + vehicle = 14, wt + taurine = 11, Ube3a^m−/p+ + vehicle = 14, Ube3a^m−/p+ + taurine = 13); female mice (wt + vehicle = 12, wt + taurine = 14, Ube3a^m−/p+ + vehicle = 12, Ube3a^m−/p+ + taurine = 14). Data are shown, for each time point, as media ± SEM. Effect of genotype: *** p < 0.001; effect of taurine treatment on Ube3a^m+/p+ genotype: ^§ p < 0.05; effect of taurine treatment on Ube3a^m−/p+ genotype: ^# p < 0.05, ^## p < 0.01, ^### p < 0.001.