Table 1.
Average molecular weights and the polydispersity index (PDI) determined by Size Exclusion Chromatography (SEC) and elemental analysis of dextran 5, carboxylated dextran derivatives 6 and 9, and TSPO ligand conjugates 7, 8, 10 and 11.
| Compound | Mna | Mwb | Mpc | PDI | Elemental Analysis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Calculated d | Found | |||||||||
| (kDa ± SD) | (Mw/Mn) | %C | %H | %N | %C | %H | %N | |||
| 5 | 25.1 ± 0.5 | 42.9 ± 0.5 | 27.7 ± 0.5 | 1.71 | 44.44 | 6.17 | - | 44.19 | 6.60 | - |
| 6 | 56.1 ± 0.5 | 105.5 ± 2.5 | 64.4 ± 0.5 | 1.88 | 46.22 | 5.94 | - | 44.27 | 5.99 | - |
| 7 | 73.3 ± 2.5 | 128.4 ± 1.8 | 82.2 ± 0.9 | 1.75 | 48.69 | 5.86 | 3.83 | 48.08 | 5.90 | 3.59 |
| 8 | 79.9 ± 0.4 | 155.8 ± 2.2 | 87.7 ± 1.5 | 1.95 | 49.27 | 5.44 | 3.68 | 48.52 | 5.56 | 3.10 |
| 9 | 62.3 ± 0.5 | 117.7 ± 2.0 | 77.2 ± 0.7 | 1.89 | 44.87 | 5.91 | - | 44.84 | 5.93 | - |
| 10 | 85.4 ± 1.2 | 161.4 ± 5.5 | 90.8 ± 2.0 | 1.89 | 51.38 | 5.64 | 3.77 | 50.83 | 5.68 | 3.47 |
| 11 | 80.7 ± 0.5 | 162.2 ± 8.2 | 89.0 ± 1.0 | 2.01 | 52.66 | 4.95 | 5.91 | 52.04 | 5.04 | 5.47 |
a Number average (Mn) molecular weight; b weight average (Mw) molecular weight; c molar mass at the peak maximum molecular weight (Mp); d Calculated on the basis of the TSPO ligand conjugation degree (see Table 2).