BTK	Broton’s tyrosine kinase
RA	Rheumatoid Arthritis
BCR	B-cell receptor
NSAIDs	non-steroidal anti-inflammatory drug
SAARDs	slow acting anti-rheumatic drugs
DMARDs	disease-modifying anti rheumatic drugs
3D-QSAR	three-dimensional quantitative structure–activity relationship
CoMFA	comparative molecular field analysis
CoMSIA	comparative molecular similarity indices analysis
PLS	partial least square
XLA	X-linked agammaglobulinemia
ALL	acute lymphoblastic leukemia
CML	chronic myeloid leukemia
CLL	chronic lymphocytic leukemia