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. 2018 Apr 19;19(4):1236. doi: 10.3390/ijms19041236

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A summary of oligomer forming interfaces of CD81 and CD9. (A,B) Top and side view showing two possible binding modes of CD81 monomer (yellow) as predicted by flexible side-chain docking. The yellow-orange CD81 dimer displays a strong non-covalent interaction, while the less stable yellow-lime CD81 dimer can be further stabilized by formation of an intermolecular disulphide bridge. The Cys residues are shown in pink. A rotation of the covalently bound lime CD81 moiety could recruit another CD81 subunit leading to stepwise formation of CD81 oligomer stretch (see Figure 10); (C) The CD9 dimer (shades of blue) displaying two potential binding modes with CD81 moiety (yellow) as predicted by flexible side-chain docking.