Figure 4.

Effect of α7 nAChR knockdown on behaviour in tests of depression‐like phenotypes. Time spent immobile in (A) the tail suspension and (B) forced swim tests following α7 nAChR knockdown in the hippocampus of C57BL/6J male mice. In the forced swim test, data are split into 5‐ and 10‐min time bins and represent the same assay; 10 animals were used per treatment group in the final analyses. Data are expressed as means ± SEM, and dots represent individual data points. Inset represents an example of viral infection (GFP‐positive cells in the dorsal hippocampus/DG). *P < 0.05, significantly different as indicated; ANOVA and partial least squares differences post hoc tests, for each time point.