Table 2.
Summary of quantitative results of behavioral studies
| Test | Sex | Treatment | |||
|---|---|---|---|---|---|
| Saline | GTS‐21 | MLA | |||
| Light–dark box (s) | Females | 229.5 ± 5.5 | 221.5 ± 10.5 | 238.1 ± 8.0 | |
| Light–dark box (s) | Males | 227.8 ± 5.7 | 233.9 ± 11.4 | 213.6 ± 8.0 | |
| Marble burying (number buried) | Females | 6.6 ± 0.8 | 5.8 ± 1.1 | 7 ± 1 | |
| Marble burying (number buried) | Males | 6.9 ± 1 | 4.5 ± 0.7 | 4.4 ± 1.2 | |
| TST (s) | Females | 164.4 ± 11.6 | 164.2 ± 8.9 | 54.9 ± 23.27 | |
| FST (s) | Females | 118.6 ± 6.7 | 139.1 ± 7.3 | 117.6 ± 12 | |
| Social defeat (%) | Males | 139.2 ± 12.9 | 123.3 ± 12.1 | 121.4 ± 10.1 | |
| Test | Sex | Treatment | |||
|---|---|---|---|---|---|
| Saline/saline | Physo/saline | Saline/MLA | Physo/MLA | ||
| c‐fos DG (counted cells) | Females | 53.2 ± 4.4 | 60.8 ± 2.9 | 51.6 ± 1.4 | 40.1 ± 2.4 |
| c‐fos CA1 (counted cells) | Females | 35.4 ± 2.4 | 48 ± 2.2 | 44 ± 1.9 | 39.6 ± 1.2 |
| Test | Sex | Treatment | |||
|---|---|---|---|---|---|
| Scr ShRNA/saline | Scr ShRNA/physo | a7 KD/saline | a7 KD/physo | ||
| Light–dark box (s) | Females | 219.2 ± 6.9 | 249.5 ± 8.1 | 220 ± 5.4 | 218.6 ± 4.9 |
| TST (s) | Females | 144.1 ± 14 | 173.4 ± 12.3 | 161.1 ± 14 | 169.9 ± 11.3 |
| FST (s) | Females | 130.7 ± 8.7 | 139 ± 9.3 | 147.7 ± 13.7 | 123 ± 11.8 |
| Social defeat (%) | Males | 122.3 ± 21.5 | 192. ± 121.6 | 98.6 ± 7.6 | 225.6 ± 43.9 |
| Locomotion (beam breaks) | Females | 3632 ± 716 | 3354 ± 187 | 2368 ± 521 | 1948 ± 308 |
±SEM. FST, forced swim test; TST, tail suspension test.