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Structural alteration of NSF in comt mutants. (A) The amino acid alterations in the NSF-1 protein relative to the previously defined functional domains are depicted diagrammatically. Lethal alleles are indicated in bold. (B) The locations of the mutations found in the D1 or D2 domain are modeled onto the crystal structure reported for the D2 domain. (C) The location of the G58D change in the DN34 allele is modeled onto the crystal structure reported for the N-terminal domain of NSF.
