Table 2.
Summary of the parameters used in generating the data from Equation (A22) for the simulations of analysis by Equation (6)
| Parameter | Response 1 | Response 2 | ||
|---|---|---|---|---|
| True mean | Simulated | True mean | Simulated | |
| E max | 1.50 | 1.67 ± 0.17 | 50 | 44.0 ± 11.8 |
| bkgd | 0.90 | 0.95 ± 0.10 | 5.0 | 5.2 ± 1.2 |
| logχ 1 | −0.30 | −0.30 ± 0.15 | −0.12 | −0.06 ± 0.14 |
| logχ 2 | −0.90 | −0.93 ± 0.20 | −0.73 | −0.62 ± 0.15 |
| logε A | 1.70 | 1.77 ± 0.12 | 1.70 | 1.60 ± 0.18 |
| logε B | −1.00 | −0.96 ± 0.11 | −2.00 | −2.00 ± 0.31 |
| logε C | 1.00 | 0.93 ± 0.16 | −0.52 | −0.45 ± 0.19 |
| logε D | 1.48 | 1.39 ± 0.10 | 2.30 | 2.33 ± 0.24 |
| pK aA | −0.52 | −0.56 ± 0.12 | −0.52 | −0.35 ± 0.26 |
| pK aB | −2.00 | −2.07 ± 0.14 | −2.00 | −1.87 ± 0.23 |
| pK aC | −1.00 | −1.04 ± 0.08 | −1.00 | −0.96 ± 0.19 |
| pK aD | 0.00 | 0.08 ± 0.14 | 0.00 | 0.06 ± 0.20 |
| log(n) | 0.18 | 0.16 ± 0.04 | −0.10 | −0.15 ± 0.09 |
Values are the mean ± SD of the six simulated sets of parameters. Subscripts A–D refer to the four ligands. Subscripts 1 and 2 refer to the different receptor expression levels.