Table IV.
The 10 most upregulated and downregulated mRNAs in high-grade ovarian serous cancer tissues compared with non-tumor tissues, compared by volcano plot.
| A, Upregulated mRNAs
| ||||
|---|---|---|---|---|
| Seq. name | Gene symbol | Fold change | Chromosome | Description |
| NM_153426 | PITX2 | 333.42 | chr4 | Paired-like homeodomain 2 |
| NM_001884 | HAPLN1 | 184.94 | chr5 | Hyaluronan and proteoglycan link protein 1 |
| NM_002125 | HLA-DRB5 | 184.27 | chr6 | Major histocompatibility complex, class II, DR beta 5 |
| NM_021192 | HOXD11 | 119.74 | chr2 | Homeobox D11 |
| NM_014391 | ANKRD1 | 112.86 | chr10 | Ankyrin repeat domain 1 (cardiac muscle) |
| NM_003108 | SOX11 | 111.46 | chr2 | SRY-box 11 |
| NM_001854 | COL11A1 | 106.05 | chr1 | Collagen, type XI, alpha 1 |
| NM_003469 | SCG2 | 93.91 | chr2 | Secretogranin II |
| NM_005733 | KIF20A | 91.34 | chr5 | Kinesin family member 20A |
| NM_022346 | NCAPG | 74.57 | chr4 | Non-SMC condensin I complex subunit G |
|
| ||||
| B, Downregulated mRNAs
| ||||
| Seq. name | Gene symbol | Fold change | Chromosome | Description |
|
| ||||
| NM_176813 | AGR3 | 2696.97 | chr7 | Anterior gradient 3, protein disulphide isomerase family member |
| NM_006408 | AGR2 | 1914.59 | chr7 | Anterior gradient 2, protein disulphide isomerase family member |
| NM_053285 | TEKT1 | 1848.50 | chr17 | Tektin 1 |
| NM_003357 | SCGB1A1 | 1791.03 | chr11 | Secretoglobin family 1A member 1 |
| NM_031956 | TTC29 | 1334.47 | chr4 | Tetratricopeptide repeat domain 29 |
| NM_001004303 | C1orf168 | 1088.35 | chr1 | Chromosome 1 open reading frame 168 |
| NM_001080537 | SNTN | 1051.19 | chr3 | Sentan, cilia apical structure protein |
| NM_000777 | CYP3A5 | 1007.52 | chr7 | Cytochrome P450 family 3 subfamily A member 5 |
| NM_024730 | RERGL | 778.24 | chr12 | RERG/RAS-like |
| NM_005634 | SOX3 | 752.28 | chrX | SRY-box 3 |