Figure 5.

Effects of open‐channel blockers on nACh receptor activity as a function of the unblocking rate. Single‐channel currents for muscle nACh receptor activated by 100 μM ACh were simulated on the basis of the linear open‐channel blocking scheme, including a closed (C), an open (O) and a blocked state (OB). A desensitized state was also included to allow the termination of the bursts in the simulations. Rate constants are β = 50 000 s⁻¹ (opening rate), d + = 100 s⁻¹ (desensitization rate), d‐ = 1 s⁻¹ (recovery from desensitization), k_+b = 1 × 10⁷ M⁻¹ s⁻¹, [B] = 5 mM, k_‐b = 700, 7000 or 70 000 s⁻¹.