Figure 6.
Potentiation of human α7 receptors by type I and type II PAMs as a function of temperature. Single‐channel currents of human α7 receptors activated by 100 μM ACh in the absence and presence of potentiators. The increase of temperature reduces the long clusters induced by PNU‐120596 but does not affect significantly the duration of bursts induced by 5‐HI. Channel openings are shown as upward deflections. Membrane potential: −70 mV. ACh: 100 μM, PNU‐120596: 1 μM, 5‐HI: 2 mM.