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. 2017 Aug 24;175(11):1999–2012. doi: 10.1111/bph.13914

Table 1.

Agonist actions of ACh on wild‐type and mutant Dα1β2 nicotinic ACh receptors expressed in Xenopus oocytesa

(Dα1)3(β2)2 (Dα1)2(β2)3
nACh receptors pEC50 Imax pEC50 Imax
Wild type 7.05 ± 0.06 0.981 ± 0.031 6.74 ± 0.05 1.026 ± 0.031
R57S 6.97 ± 0.06 0.985 ± 0.031 6.67 ± 0.05 1.035 ± 0.031
K140T 6.89 ± 0.05 0.978 ± 0.026 6.66 ± 0.04 1.009 ± 0.024
R57S;K140T 6.90 ± 0.05 1.006 ± 0.030 6.81 ± 0.07 1.071 ± 0.038
E78K 7.04 ± 0.04 0.979 ± 0.021 7.02 ± 0.05* 1.036 ± 0.023
R57S;E78K;K140T 7.00 ± 0.04 0.977 ± 0.024 6.83 ± 0.08 0.995 ± 0.043
a

Data are presented as mean ± SEM of repeated experiments (n = 5).

*

The pEC50 (‐log EC50) value differed significantly from that determined in the wild type (P < 0.05).