Table 1.
(Dα1)3(β2)2 | (Dα1)2(β2)3 | |||
---|---|---|---|---|
nACh receptors | pEC50 | Imax | pEC50 | Imax |
Wild type | 7.05 ± 0.06 | 0.981 ± 0.031 | 6.74 ± 0.05 | 1.026 ± 0.031 |
R57S | 6.97 ± 0.06 | 0.985 ± 0.031 | 6.67 ± 0.05 | 1.035 ± 0.031 |
K140T | 6.89 ± 0.05 | 0.978 ± 0.026 | 6.66 ± 0.04 | 1.009 ± 0.024 |
R57S;K140T | 6.90 ± 0.05 | 1.006 ± 0.030 | 6.81 ± 0.07 | 1.071 ± 0.038 |
E78K | 7.04 ± 0.04 | 0.979 ± 0.021 | 7.02 ± 0.05* | 1.036 ± 0.023 |
R57S;E78K;K140T | 7.00 ± 0.04 | 0.977 ± 0.024 | 6.83 ± 0.08 | 0.995 ± 0.043 |
Data are presented as mean ± SEM of repeated experiments (n = 5).
The pEC50 (‐log EC50) value differed significantly from that determined in the wild type (P < 0.05).