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. 2018 Apr 24;42(1):381–391. doi: 10.3892/ijmm.2018.3639

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Copyright: © Ding et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Downregulation of Rab10 inhibits ESCC cell line invasion and migration. (A) Cell migration was analyzed in EC109 and KYSE150 cells using a wound healing assay (magnification, ×100). (B) Invasive ability of cells was quantified by counting the number of cells that invaded the underside of the porous polycarbonate membrane in a Transwell invasion assay (magnification, ×200). (C) Protein levels were assayed in ESCC cell lines. (D) Association between Rab10 and miR-378a-3p in ESCC tissues. For each experiment, n=3 (^**P<0.01, vs. control). ESCC, esophageal squamous cell carcinoma; NC, negative control; siRab10, small interfering RNA targeting Rab10; MMP, matrix metalloproteinase.