Table IV.
The enriched GO functions for the upregulated and downregulated miRNAs involved in the DE-miRNA-DEG regulatory network.
| Category | Term | Description | miRNA no. | miRNA symbol | p-value |
|---|---|---|---|---|---|
| UP_BP | 0048386 | Positive regulation of retinoic acid Receptor signaling pathway | 6 | miR-221, miR-18a | 0.000211583 |
| 0060523 | Prostate epithelial cord elongation | 6 | miR-20b, miR-18a | 0.001058491 | |
| 0060745 | Mammary gland branching involved in pregnancy | 6 | miR-221, miR-20b | 0.001196154 | |
| 0001766 | Membrane raft polarization | 2 | miR-125a-5p, miR-128 | 0.002429205 | |
| 0030885 | Regulation of myeloid dendritic cell activation | 2 | miR-125a-5p, miR-128 | 0.002429205 | |
| 0030887 | Positive regulation of myeloid dendritic cell activation | 2 | miR-125a-5p, miR-128 | 0.002429205 | |
| UP_MF | 0031798 | Type 1 metabotropic glutamate receptor binding | 6 | miR-221, miR-20b | 0.000150457 |
| 0030235 | Nitric-oxide synthase regulator activity | 6 | miR-19b, miR-20b | 0.000413057 | |
| 0035256 | G-protein coupled glutamate receptor binding | 6 | miR-19b, miR-18a | 0.000413057 | |
| 0030284 | Estrogen receptor activity | 6 | miR-19a, miR-18a | 0.002145221 | |
| 0034056 | Estrogen response element binding | 6 | miR-19b, miR-19a | 0.003216968 | |
| 0031779 | Melanocortin receptor binding | 3 | miR-455-5p, miR-125a-5p, miR-484 | 0.009585627 | |
| 0031781 | Type 3 melanocortin receptor binding | 3 | miR-455-5p, miR-484, miR-125a-5p | 0.009585627 | |
| DOWN_BP | 0014854 | Response to inactivity | 4 | miR-133b, miR-206 | 0.001989302 |
| 0014870 | Response to muscle inactivity | 4 | miR-1, miR-133b | 0.001989302 | |
| 0014877 | Response to muscle inactivity involved in regulation of muscle adaptation | 4 | miR-206, miR-1 | 0.001989302 | |
| 0014894 | Response to denervation involved in regulation of muscle adaptation | 4 | miR-1, miR-133b | 0.001989302 | |
| 0002368 | B cell cytokine production | 2 | miR-206, miR-1 | 0.002474699 | |
| 0002424 | T cell mediated immune response to tumor cell | 2 | miR-1, miR-206 | 0.002474699 | |
| DOWN_ MF | 0005008 | Hepatocyte growth factor-activated receptor activity | 4 | miR-133b, miR-206 | 0.001415624 |
| 0030955 | Potassium ion binding | 4 | miR-206, miR-140-3p | 0.006643278 | |
| 0031420 | Alkali metal ion binding | 4 | miR-133b, miR-1 | 0.007459611 | |
| 0003688 | DNA replication origin binding | 2 | miR-206, miR-1 | 0.014287542 | |
| 0031078 | Histone deacetylase activity (H3-K14 specific) | 4 | miR-206, miR-140-3p | 0.016613831 | |
| 0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | 4 | miR-1, miR-206 | 0.016613831 |
DEG, differentially expressed gene; BP, biological process; MF, molecular function.