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Fisetin ameliorates the acute otitis media in the middle ear of lipopolysaccharides (LPS)-treated mice by inhibiting MAPK signaling pathway. (A) p-p38 and (B) p-ERK1/2 levels were determined via the immunofluorescent analysis. The quantification of phosphorylated p38 and ERK1/2 is shown. Data are expressed as the mean ± SEM (n=10). *p<0.05, **p<0.01 and ***p<0.001 vs. the control (Con) group; +p<0.05, ++p<0.01 and +++p<0.001 vs. the LPS group.
