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. 2018 Apr 26;42(1):299–308. doi: 10.3892/ijmm.2018.3645

Figure 6.

Figure 6

Summary of the CD4+ T cell-induced immunomodulatory effects of BSNXD on osteoclast differention. BSNXD suppresses ovariectomy-induced increases in CD4+ T cells subsets, adjusting the RANKL/OPG imbalance and the translation of these immunomodulatory effects on skeletal parameters such as osteoclastogenesis. BMMs, bone marrow-derived macrophages; BSNXD, Bu-Shen-Ning-Xin Decoction; RANKL, receptor activation of nuclear factor κB ligand-RANK, nuclear factor κB ligand; OPG, osteoprotegerin; CD, cluster of differentiation.