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. 2018 Mar 26;8:5209. doi: 10.1038/s41598-018-21965-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of the hda1Δ mutant strain on virulence as assessed by the murine inhalational model of infection. (A) Ten C57BL/6 female mice were intranasally inoculated with the wild-type, hda1Δ, or hda1∆ + HDA1 strain to establish an infection. Animal survival was monitored for 40 days. Statistical test: Kaplan-Meier method. p < 0.0001 (B) Lungs and (C) brains of infected animals were harvested 14 days post infection, and quantitative cultures per mg tissue were performed. Statistical test: One-way ANOVA with Dunnett’s posttest. (D) Histopathological analysis of H&E-stained lung tissue from animals infected with the indicated strains after 14 days of infection.