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. 2018 Mar 26;8:5209. doi: 10.1038/s41598-018-21965-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The transcriptional signature of the hda1∆ mutant versus wild-type. (A) Hda1-dependent upregulated and downregulated genes in the hda1∆ mutant versus wild-type as determined by two independent RNA-Seq analysis pipelines. Graph represents values from STAR/DeSeq2 analysis. (B) Modified gene ontology enrichment analysis of Hda1-dependent genes. The percent of genes differentially expressed in the hda1∆ strain versus wild-type in each category is plotted on the x-axis. Colors represent the proportion of differentially expressed genes in each category positively or negatively regulated by HDA1. Statistical test: Chi-square of observed versus expected frequency of 5%; ****p < 0.0001.