Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 26;8:5209. doi: 10.1038/s41598-018-21965-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Model for HDAC regulation of the main virulence phenotypes in C. neoformans. Cells sense environmental cues (pH, high temperature, stress nutritional etc.) through membrane receptors and a signal is transmitted into the cell. The signal results in an adaptive response that requires chromatin remodeling mediated by the balance between HAT and HDAC activity. HDAC enzymes play a role in the regulation of the expression of all virulence phenotypes shown in the scheme. The loss of HDAC enzymes interferes with the correct adaptive response to environmental signals and impairs virulence factor expression.