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. 2018 Mar 26;8:5171. doi: 10.1038/s41598-018-23554-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RLR-containing 15-mer MIF peptides block MIF/CXCR4-dependent JVM-3 lymphocyte chemotaxis. Chemotactic migration (represented as chemotactic index) of JVM-3 lymphocytes towards WT-MIF (16 nM) in the presence versus absence of different concentrations of RLR-containing peptides MIF(76–90) or YSKLLCGLLAERLRI and MIF(86–100) or ERLRISPDRVYINYY as indicated. PBS buffer was used as negative control to normalize for spontaneous random migration (control). The bar graph shows means ± SD of 3–12 replicates and represent 2–3 experiments. Statistical comparisons were done between the MIF and MIF + peptide data sets (*p < 0.05; ***p < 0.005) and between control and MIF (^§§§p < 0.005).