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. 2018 Mar 26;8:5192. doi: 10.1038/s41598-018-23514-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes in parasitic and free-living adult female life cycle stages for four Strongyloides species – S. venezuelensis, S. papillosus, S. ratti and S. stercoralis. (A) Proportion of genes upregulated in the parasitic and free-living adult female life cycle stages of four Strongyloides spp. Total area of the circle is proportional to the total number of predicted protein-coding genes in the genome (total gene number shown in grey boxes). Proportion of genes differentially expressed for a parasitic female (PF) vs. free-living females (FLF) pairwise comparison, determined by edgeR analysis are highlighted (PF – stripes, FLF – squares). (B,C) The six most commonly upregulated gene families are displayed for the parasitic (B) and free-living (C) stages of the life cycle n.b. different y-axis scales. *Represents families where distinct sets of genes belonging to the same family are differentially expressed in both life cycle stages.