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. 2018 Mar 26;8:4997. doi: 10.1038/s41598-018-23177-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of a sub-group of prostate cancer cases with low aggressive potential. (A) A 3D illustration of the mean values of principal component (PC) 4, as calculated from individual Hb samples vs. prostate weight and the percentage of stroma in samples for the training cohort. The subgroup of samples in the Low aggressive group, identified by a threshold of one standard deviation below the mean (M-SD), is highlighted by dark blue points. (B) The values of PC4 calculated for the testing cohort according to parameters obtained from the training cohort can identify 10 from 58 (17%) Low aggressive cases, using the threshold of M-SD measured from Hb samples (below the brown dashed line). Prostate cancer, BPH, and Bx values are also presented for references.