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. 2018 Mar 26;8:5166. doi: 10.1038/s41598-018-23201-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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pylT enables the faithful encoding of lysine into position K1237 of rNa_v 1.4. (a) Example traces of rNa_v 1.4-K1237TAG cRNA coinjected with either lysine-acylated (top) or unacylated full length (bottom) PylT. Oocytes were held at −100 mV and pulsed from −80 mV to +40 mV with 30 ms depolarizing steps. Voltage gated sodium channel activity is evidenced by increasingly large downward deflections in the traces in response to depolarization. The level of zero current for each cell is indicated by a dashed line. (b) Normalized current-voltage relationship plots comparing the WT rNa_v 1.4 channel to that of the rNa_v 1.4 K1237TAG rescued with lysine.