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. 2018 Mar 26;8:5212. doi: 10.1038/s41598-018-23567-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of furin inhibitors (a,b) as well as several protease inhibitors (c–e) on NMDA-induced cell injury. Cell viability in cultures of cortical neurons treated with 0 µM (white bars) or 30 µM NMDA (black bars) without or with the indicated concentrations of furin inhibitor 1 (a), furin inhibitor 2 (b), γ-secretase inhibitor (c), MMP inhibitor (d) or PCSK9 inhibitor (e). The relative cell viability was expressed as the percentage of the absorbance at 450 nm of each treatment group against that of the untreated control group. Results are the means ± SE (n = 4 independent experiments). *Indicates a significant difference from the NMDA- and corresponding inhibitor-untreated group (p < 0.05); and ^#, a significant difference from the NMDA-treated and furin inhibitor 1- untreated group (p < 0.05).