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. 2018 Mar 26;8:5202. doi: 10.1038/s41598-018-23450-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Results of average and SEM of weighting values of individual biomarkers and their classification rates. We focused on the difference in strains after the vehicle administration (left column), effects of MPH (centre column) and ATX (right column) compared with the vehicle, and discerned the weighting parameters via FDA for slope features (panel A), intercept features (panel B), mPower features (panel C), both slope and intercept features (panel D), and both slope and mPower features (panel E) in lDelta–Beta frequency bands. Bar plots depict the average and SEM of individual normalized weighting parameters, and values show average ±SEMs of classification rates via 10-fold CV test. Since the scale of slope and intercept parameters, and individual frequency bands are quite different (e.g., lDelta > delta > Theta > Alpha > Beta), individual weighting parameters were normalized depending on the individual scale, as ascertained for this visualization. Note that this normalization does not have any effect on the classification accuracy.