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. 2018 Mar 26;8:5158. doi: 10.1038/s41598-018-23568-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alcohol interferes with Hcy metabolism leading to hyperhomocysteinemia (HHcy). (a,b) Scatter dot plots represent data for the CBS enzyme activity and total homocysteine (tHcy) levels in the different mice groups. (c–f) Representative western blot analysis for the vital enzymes (CBS, CSE, MTHFR, SAHH and Hcy) involved in homocysteine metabolism in different mice groups. Bar graphs showing quantitative estimation of key proteins after normalization with GAPDH. (g,h) q-PCR analysis showing the data for real‐time transcript levels of CBS, CSE, MTHFR and SAHH mRNAs in the different groups of mice. All the data are represented as mean values ± standard error (SE) in 5 independent experiments. *^,#p < 0.05 considered significant. *p < 0.05 vs. CT and ^#p < 0.05 vs. AL group.Uncropped blots for c and e are presented in Supplementary Figs 1 and 2.