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In vivo pharmacokinetics and ex vivo biodistribution studies. A,B) In vivo pharmacokinetic profiles of free DOX plus CDDP and CDDP3.3HANG/DOX5.4 in rats. C) Ex vivo DOX fluorescence images and D) average signals of the tumors and major organs at 6 and 12 h postinjection of free DOX plus CDDP and CDDP3.3HANG/DOX5.4 into K7 osteosarcoma‐xenografted BALB/c mice. Data are represented as mean ± SD (n = 3 for A, B and D, ** P < 0.01, *** P < 0.001).
