Table 4.
Odds ratios (OR) and 95% CI for the associations between plasma metabolite levels and pancreatic cancer during the first 6 y of follow up
| Metabolite | Pancreatic cancer diagnosed in the first 6 y of follow up (n = 48) | ||||
|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P for trend | |
| Xylitol | |||||
| Median, μg/mL | 0.06 | 0.12 | 0.29 | 0.49 | |
| Cases (n)/controls (n) | 12/27 | 23/42 | 8/11 | 5/16 | |
| OR (95% CI)a | 1.00 (reference) | 0.91 (0.26‐3.20) | 1.00 (0.12‐8.58) | 0.39 (0.05‐3.09) | .29 |
| 1,5‐AG | |||||
| Median, μg/mL | 15.5 | 22.2 | 30.3 | 41.7 | |
| Cases (n)/controls (n) | 16/22 | 16/16 | 10/33 | 6/25 | |
| OR (95% CI)a | 1.00 (reference) | 1.44 (0.47‐4.37) | 0.29 (0.08‐1.00) | 0.37 (0.08‐1.66) | .04 |
| Histidine | |||||
| Median, nmol/mL | 66.1 | 81.1 | 89.3 | 100.8 | |
| Cases (n)/controls (n) | 6/11 | 13/20 | 11/22 | 18/43 | |
| OR (95% CI)a | 1.00 (reference) | 1.15 (0.20‐6.43) | 0.68 (0.12‐3.72) | 0.66 (0.14‐3.17) | .31 |
| Inositol | |||||
| Median, μg/mL | 2.79 | 3.67 | 4.40 | 5.81 | |
| Cases (n)/controls (n) | 8/20 | 9/22 | 8/28 | 23/26 | |
| OR (95% CI)a | 1.00 (reference) | 1.30 (0.37‐4.51) | 1.14 (0.28‐4.58) | 3.23 (0.90‐11.63) | .054 |
| Threonine | |||||
| Median, nmol/mL | 174.5 | 213.0 | 249.0 | 316.7 | |
| Cases (n)/controls (n) | 7/11 | 14/24 | 13/30 | 14/31 | |
| OR (95% CI)a | 1.00 (reference) | 0.77 (0.18‐3.26) | 0.52 (0.15‐1.81) | 0.51 (0.13‐1.96) | .22 |
| Methionine | |||||
| Median, nmol/mL | 20.9 | 24.6 | 27.5 | 36.7 | |
| Cases (n)/controls (n) | 5/13 | 10/20 | 19/30 | 14/33 | |
| OR (95% CI)a | 1.00 (reference) | 1.30 (0.34‐4.95) | 1.70 (0.46‐6.31) | 0.77 (0.17‐3.44) | .79 |
| Arabinose | |||||
| Median, μg/mL | 0.18 | 0.23 | 0.31 | 0.58 | |
| Cases (n) / controls (n) | 9/14 | 16/21 | 9/32 | 14/29 | |
| OR (95% CI)a | 1.00 (reference) | 0.91 (0.26‐3.16) | 0.21 (0.04‐1.04) | 0.49 (0.09‐2.57) | .26 |
| Asparagine | |||||
| Median, nmol/mL | 45.9 | 53.2 | 61.3 | 74.8 | |
| Cases (n)/controls (n) | 13/16 | 15/23 | 8/25 | 12/32 | |
| OR (95% CI)a | 1.00 (reference) | 0.97 (0.34‐2.74) | 0.30 (0.09‐1.02) | 0.34 (0.09‐1.28) | .04 |
| Glutamine | |||||
| Median, nmol/mL | 513.4 | 613.6 | 686.2 | 800.8 | |
| Cases (n)/controls (n) | 6/15 | 11/18 | 9/24 | 22/39 | |
| OR (95% CI)a | 1.00 (reference) | 1.14 (0.22‐5.87) | 0.62 (0.12‐3.22) | 0.93 (0.20‐4.28) | .94 |
| Lysine | |||||
| Median, nmol/mL | 167.4 | 195.6 | 225.7 | 276.5 | |
| Cases (n)/controls (n) | 6/13 | 11/19 | 10/27 | 21/37 | |
| OR (95% CI)a | 1.00 (reference) | 1.45 (0.34‐6.23) | 0.78 (0.15‐4.05) | 1.37 (0.29‐6.53) | .80 |
| Tyrosine | |||||
| Median, nmol/mL | 95.0 | 116.2 | 133.9 | 156.8 | |
| Cases (n)/controls (n) | 7/11 | 17/19 | 8/30 | 16/36 | |
| OR (95% CI)a | 1.00 (reference) | 1.82 (0.45‐7.41) | 0.35 (0.08‐1.56) | 0.42 (0.10‐1.76) | .04 |
| Uric acid | |||||
| Median, mg/dL | 3.16 | 4.77 | 5.87 | 7.95 | |
| Cases (n)/controls (n) | 11/10 | 17/29 | 10/30 | 10/27 | |
| OR (95% CI)a | 1.00 (reference) | 0.37 (0.13‐1.08) | 0.23 (0.07‐0.82) | 0.17 (0.04‐0.78) | .02 |
Based on conditional logistic regression analysis.
a
OR was adjusted for age (5‐y age group), gender, PHC area, and duration of the fasting period prior to blood sampling (less than 7 hours, 7 hours or more, or unknown), smoking, body mass index, and past history of diabetes mellitus.
CI, confidence interval; 1,5‐AG, 1,5‐anhydro‐d‐glucitol.