. 2018 Apr 27;109(5):1576–1582. doi: 10.1111/cas.13558

Table 3.

Univariate and multivariate analysis for local control and overall survival rates among 69 patients with major salivary gland carcinomas treated with carbon‐ion radiotherapy

Parameters	No. of patients	Local control			Overall survival
		Univariate analysis	Multivariate analysis		Univariate analysis	Multivariate analysis
		P‐value	P‐value	Hazard ratio	P‐value	P‐value	Hazard ratio
Age, years
<62	33	.6515	–	–	.7418	–	–
≥62	36	.6515	–	–	.7418	–	–
Sex
Male	32	.0477	.259	–	.0129	.020	10.97
Female	37	.0477	.259	–	.0129	.020	10.97
Disease status
Initial disease	52	.2132	–	–	.0352	.103	–
Recurrent disease	17	.2132	–	–	.0352	.103	–
Operability
Yes	39	.0105	.078	–	.3172	–	–
No	30	.0105	.078	–	.3172	–	–
Primary site
Parotid gland	58	.5871	–	–	.2161	–	–
Others	11	.5871	–	–	.2161	–	–
Histology
ACC	33	.8403	–	–	.8833	–	–
Others	36	.8403	–	–	.8833	–	–
Clinical T classification
1–3	36	.2601	–	–	.0089	.023	10.09
4	33	.2601	–	–	.0089	.023	10.09
Clinical N classification
0	60	.7320	–	–	.2220	–	–
1	9	.7320	–	–	.2220	–	–
GTV, mL
<27	34	.0586	–	–	.0186	.079
≥27	35	.0586	–	–	.0186	.079
BED, Gy (RBE)
<89.6	33	.0068	.034	3.815	.0828	–	–
89.6	36	.0068	.034	3.815	.0828	–	–

−, Not evaluated. ACC, adenoid cystic carcinoma; BED, biologically effective dose; GTV, gross tumor volume; RBE, relative biological effectiveness.