Table 1.
Patient and donor characteristics
| Characteristics | Low NK1 group | High NK1 group | P value |
|---|---|---|---|
| No. of patient | 18 | 22 | |
| Median age (range), years | 22 (11‐45) | 32 (6‐46) | .286 |
| Patient sex, male, No. (%) | 11 (61.1%) | 12 (54.5%) | .676 |
| Donor‐recipient gender, No. (%) | .481 | ||
| Male to male | 4 (22.2%) | 8 (36.4%) | |
| Male to female | 5 (27.8%) | 4 (18.2%) | |
| Female to male | 6 (33.3%) | 4 (18.2%) | |
| Female to female | 3 (16.7%) | 6 (27.3%) | |
| Diagnosis, No. | .28 | ||
| AML | 6 (33.3%) | 12 (54.5%) | |
| CML | 3 (16.7%) | 5 (22.7%) | |
| ALL | 8 (44.4%) | 5 (22.7%) | |
| AA | 1 (5.6%) | 0 | |
| Disease status, high risk, No. (%) | 4 (23.5%) | 4 (18.2%) | .682 |
| Conditioning regimen, NO. | |||
| Bu/Cy+ATG | 18 (100%) | 22 (100%) | |
| HLA‐A, HLA‐B, HLA‐DR mismatched grafts, No. | .761 | ||
| 0 | 7 (38.9%) | 6 (27.3%) | |
| 1 | 1 (5.6%) | 3 (13.6%) | |
| 2 | 4 (22.2%) | 6 (27.3%) | |
| 3 | 6 (33.3%) | 7 (31.8%) | |
| ABO‐matched grafts, No. (%) | .54 | ||
| Matched | 9 (50%) | 12 (54.5%) | |
| Major mismatch | 5 (27.8%) | 4 (18.2%) | |
| Minor mismatch | 4 (22.2%) | 4 (18.2%) | |
| Bidirectional mismatch | 0 (0%) | 2 (9.1%) | |
| Cell composition in allografts, median (range) | .527 | ||
| Infused CD3+ cells, 108/kg | 1.7 (0.6‐3.3) | 2.3 (0.4‐3.8) | |
| Infused NK1 cells,106/kg | 3.1 (1.0‐4.7) | 8.0 (4.9‐36.2) | <.0001 |
| Infused NK2 cells,105/kg | 2.7 (0.4‐2.0) | 4.0 (0.2‐2.1) | .581 |
| Infused NK3 cells,105/kg | 2.8 (0.52‐3.0) | 4.9 (0.6‐2.3) | .112 |
| Infused NKr cells,105/kg | 6.0 (0.11‐2.31) | 1.6 (0.38‐7.2) | .101 |