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. 2018 Feb 5;154(2):169–177. doi: 10.1111/imm.12887

Figure 4.

Figure 4

Infarct volumes after regulatory B (Breg) cell treatment of experimental stroke. (a) Intravenous transfer of 5 million IL‐10+ B cells given 24 hr before surgery to induce middle cerebral artery occlusion (MCAO) reduced infarct volume in wild‐type (WT) mice (n = 10), 96 hr following 60 min of MCAO compared with intravenous transfer of RPMI‐1640 vehicle (no cells) (n = 12). **P < 0·01. (b) Intravenous transfer of 5 million IL‐10+ B cells 4 hr after surgery to induce MCAO reduced cortical and hemispheric (total) infarct volume in WT mice (n = 13), 96 hr following 60 min of MCAO compared with intravenous transfer of RPMI‐1640 vehicle (no cells) (n = 14). *P < 0·05; ***P < 0·001. (c) Intravenous transfer of 5 million IL‐10+ B cells given 24 hr after induction of MCAO reduced infarct volume in C57BL/6J (WT) mice 96 hr after 1 hr of MCAO compared with intravenous transfer of RPMI Vehicle (no cells). *P < 0·05. (a,b) Republished with permission by Bodhankar et al.,61 p. 63, © Springer Science+Business Media New York 2013, With permission of Springer. (c) Bodhankar et al.,62 p. 915, © Springer Science+Business Media New York 2014. With permission of Springer.