Table 1.

Comparative features and some advantages of scaffold‐free biofabrication. For details, see text

Scaffold‐dependent bioprinting	Scaffold‐free biofabrication
Bioinks are essentially soft biomaterials	Cells produce optimal matrix
Hardening is non‐trivial and consequential	No stiffness adjustment necessary
A “universal” bioink is yet to be found	Biomaterials can still be optionally added
Limited intercellular communication	Natural intercellular interactions
Variable cell damage	Higher efficiency, less cell damage
Biocompatibility more difficult to attain	Easier obtained biocompatibility
Simplistic cellular architecture	Closer following of developmental principles
Good for large, cell‐homogenous, matrix‐rich tissue	Best for smaller, cell‐heterogeneous, matrix‐poor tissues