Table 1.
T‐cell differentiation pattern
| T lymphocytes | T lymphocytes | P | |
|---|---|---|---|
| Peripheral blood | Liver | ||
| n = 7 | n = 7 | ||
| Median, % (range) | Median, % (range) | ||
| CCR7− | |||
| 45RA− 27− 28− | 0·6 (0·1–3·8) | 10·5 (4·6–16·2) | < 0·001 |
| 45RA+ 27+ 28+ | 3·1 (1·3–5·7) | 4·9 (0·9–8·0) | NS |
| 45RA− 27+ 28+ | 10·4 (5·5–15·2) | 38·7 (4·1–52·2) | < 0·05 |
| 45RA− 27− 28+ | 2·0 (0·7–3·0) | 13·8 (3·7–26·1) | < 0·001 |
| 45RA− 27+ 28− | 0·5 (0·1–2·5) | 3·3 (0·5–8·4) | < 0·01 |
| 45RA+ 27− 28+ | 0·1 (0·0–0·9) | 0·6 (0·4–2·0) | NS |
| 45RA+ 27+ 28− | 2·6 (0·5–5·0) | 6·2 (2·7–8·8) | < 0·05 |
| 45RA+ 27− 28− | 1·5 (0·5–13·6) | 14·6 (3·1–61·9) | < 0·05 |
| CCR7+ | |||
| 45RA− 27− 28− | 0·0 (0·0–0·1) | 0·0 (0·0–0·2) | NS |
| 45RA+ 27+ 28+ | 43·7 (29·1–67·0) | 3·2 (1·5–10·7) | < 0·001 |
| 45RA− 27+ 28+ | 33·7 (22·4–39·3) | 3·8 (1·7–5·9) | < 0·001 |
| 45RA− 27− 28+ | 1·6 (0·5–2·6) | 0·2 (0·1–3·9) | NS |
| 45RA− 27+ 28− | 0·0 (0·0–0·1) | 0·0 (0·0–0·6) | NS |
| 45RA+ 27− 28+ | 0·0 (0·0–0·1) | 0·0 (0·0–0·2) | NS |
| 45RA+ 27+ 28− | 0·2 (0·2–0·7) | 0·2 (0·1–1·3) | NS |
| 45RA+ 27− 28− | 0·0 (0·0–0·1) | 0·0 (0·0–2·6) | NS |
Comparison of the T‐cell differentiation pattern between peripheral blood (n = 7) and liver (n = 7) CD3+ cells. Phenotypes were separated into CCR7− (upper table) and CCR7+ (lower table) populations. Data are expressed as the median (range) of cells positive for the different T‐cell subpopulations according to the combined expression of CD45RA, CD27 and CD28 referred to as the total number of T lymphocytes. Mann–Whitney U‐test.