Table 2.
Expression of killer cell immunoglobulin‐like receptors
| NK CD56bright | NK CD56dim | NKT | T | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PB | Liver | PB | Liver | PB | Liver | PB | Liver | PB | Liver | |
| Median (range) | Median (range) | Median (range) | Median (range) | Median (range) | Median (range) | Median (range) | Median (range) | n | n | |
| 2DL1 | 1·7 (0·0–17·3) | 3·0 (1·0–20·1) | 16·1 (4·1–70·4) | 10·5 (5·5–45·1) | 3·8 (0·2–30·4) | 1·2 (0·3–7·7) | 0·4 (0·0–8·8) | 1·0 (0·2–3·7) | 34 | 7 |
| 2DL1/2DS1 | 2·5 (0·0–20·7) | 1·9 (0·4–33·8) | 17·5 (2·9–65·5) | 13·2 (8·6–55·3) | 1·1 (0·0–26·8) | 2·7 (1·2–11·4) | 0·0 (0·0–4·1) | 1·2*** (0·7–5·2) | 35 | 7 |
| 2DL1/2DS1/2DS3 | 4·0 (0·6–22·5) | 5·7 (2·0–27·0) | 19·9 (8·9–70·5) | 37·1 (9·7–61·1) | 2·7 (0·0–35·3) | 3·9 (1·1–53·0) | 0·2 (0·0–6·1) | 3·7*** (0·6–42·6) | 35 | 7 |
| 2DL2/2DS2/2DL3 | 3·7 (0·5–14·2) | 7·5 (2·8–9·4) | 31·4 (7·5–67·7) | 21·0 (12–36·8) | 12·8 (0·3–34·2) | 10·6 (1·9–75·0) | 1·6 (0·0–15·9) | 5·7*** (1·4–57·9) | 25 | 7 |
| 2DL3 | 1·7 (0·0–28·8) | 8·2** (1·4–15·9) | 11·9 (4·3–44·9) | 14·1 (2·6–46·2) | 3·1 (0·0–27·8) | 15·9** (2·5–50·4) | 0·2 (0·0–15·6) | 12·9*** (1·3–36·9) | 25 | 11 |
| 3DL1 | 2·2 (0·0–11·0) | 2·1 (0·7–18·4) | 16·4 (4·2–59·8) | 7·8 (1·7–36·4) | 5·9 (0·0–24·7) | 1·5 (0·2–15·6) | 0·7 (0·0–8·0) | 1·2 (0·2–8·1) | 31 | 6 |
| 3DL2a | 4·1 (0·0–18·1) | 12·9** (4·4–33·8) | 15·3 (4·9–44·3) | 31·2 (8·0–58·8) | 6·6 (0·2–45·3) | 15·6 (3·8–39·1) | 1·6 (0·0–12·6) | 8·6*** (4·2–36·2) | 35 | 7 |
| 2DS1a | 1·2 (0·0–15·4) | 0·0 (0·0–13·7) | 6·1 (0·7–19·1) | 8·7 (2·1–10·2) | 0·0 (0·0–1·9) | 2·0** (0·6–6·8) | 0·0 (0·0–0·2) | 1·0** (0·1–3·7) | 19 | 5 |
| 2DL2/2DS2a | 1·8 (0·0–13·2) | 0·7 (0·0–3·9) | 20·6 (2·9–35·6) | 7·4 (2·0–19·8) | 5·9 (0·0–23·1) | 5·3 (0·0–24·6) | 0·8 (0·0–2·6) | 3·1 (0·0–22·9) | 22 | 7 |
| 2DS3a | 3·2 (0·0–17·6) | 4·7 (0·0–8·0) | 14·5 (0·7–53·1) | 28·1 (4·0–28·5) | 3·6 (0·2–25·6) | 2·7 (0·0–44·9) | 0·5 (0·0–2·6) | 3·1* (0·1–38·6) | 15 | 4 |
| 2DS4 | 5·7 (0·1–21·1) | 7·3 (2·8–17·5) | 44·1 (5·9–69·5) | 22·2** (2·1–49·4) | 4·2 (1·2–32·5) | 12·6 (1·6–60·1) | 0·4 (0·0–6·3) | 11·3*** (1·2–45·5) | 16 | 12 |
Abbreviations: KIR, killer cell immunoglobulin‐like receptor; NK, natural killer; NKT, natural killer T; PB, peripheral blood.
Killer cell immunoglobulin‐like receptor expression in NK, NKT and T cells in peripheral blood and liver samples obtained from healthy individuals. Data are expressed as the median (range) of a specific marker within NK CD56bright, NK CD56dim, NKT and T populations. *P < 0·05, **P < 0·01, ***P < 0·001, Mann–Whitney U‐test.
a
Inferred KIR expression (see text).