Table 3.
Logistic regression analysis of associations between the genotypes of GSTM3 and ccRCC susceptibility
| Variants | Genotypes | Cases No. (%) n = 329 | Controls No. (%) n = 420 | Crude OR (95% CI) | P a | Adjusted OR (95% CI) | P b |
|---|---|---|---|---|---|---|---|
| rs1537236 (HWE = 0.417) | AA | 229 (69.6) | 281 (66.9) | 1.00 (Reference) | 1.00 (Reference) | ||
| AG | 89 (27.0) | 122 (29.0) | 0.90 (0.65‐1.24) | .511 | 0.95 (0.72‐1.34) | .693 | |
| GG | 11 (3.3) | 17 (4.0) | 0.79 (0.37‐1.73) | .697 | 0.86 (0.44‐1.89) | .825 | |
| AG + GG | 100 (30.3) | 139 (33.0) | 0.86 (0.65‐1.20) | .477 | 0.92 (0.72‐1.35) | .602 | |
| A allele | 547 (83.1) | 684 (81.4) | 1.00 (Reference) | 1.00 (Reference) | |||
| G allele | 111 (16.6) | 156 (19.6) | 0.89 (0.88‐1.16) | .415 | 0.95 (0.94‐1.23) | .579 | |
| rs3814309 (HWE = 0.695) | CC | 179 (54.4) | 243 (57.9) | 1.00 (Reference) | 1.00 (Reference) | ||
| CT | 127 (38.6) | 151 (36.0) | 1.14 (0.84‐1.55) | .436 | 1.18 (0.89‐1.63) | .522 | |
| TT | 23 (7.0) | 26 (6.2) | 1.20 (0.66‐2.17) | .546 | 1.35 (0.79‐2.34) | .621 | |
| CT + TT | 150 (45.6) | 177 (42.2) | 1.15 (0.86‐1.54) | .373 | 1.23 (0.91‐1.79) | .427 | |
| C allele | 485 (73.7) | 637 (75.8) | 1.00 (Reference) | 1.00 (Reference) | |||
| T allele | 173 (26.3) | 203 (24.2) | 1.12 (0.89‐1.42) | .368 | 1.24 (0.91‐1.47) | .479 | |
| rs1109138 (HWE = 0.510) | AA | 21 (6.4) | 15 (3.6) | 1.00 (Reference) | 1.00 (Reference) | ||
| AG | 85 (25.8) | 118 (28.1) | 0.79 (0.48‐1.30) | .370 | 0.84 (0.56‐1.51) | .491 | |
| GG | 223 (67.8) | 287 (68.3) | 0.86 (0.55‐1.37) | .559 | 0.91 (0.67‐1.59) | .672 | |
| AG + GG | 308 (93.6) | 405 (96.4) | 0.84 (0.54‐1.31) | .493 | 0.90 (0.62‐1.56) | .569 | |
| A allele | 127 (19.3) | 148 (17.6) | 1.00 (Reference) | 1.00 (Reference) | |||
| G allele | 531 (80.7) | 692 (82.4) | 0.99 (0.79‐1.26) | 1.000 | 0.99 (0.80‐1.29) | 1.000 | |
| rs1055259 (HWE = 0.728) | AA | 252 (76.6) | 289 (68.8) | 1.00 (Reference) | 1.00 (Reference) | ||
| AG | 68 (20.7) | 120 (28.6) | 0.65 (0.46‐0.92) | .014 | 0.61 (0.43‐0.90) | .012 | |
| GG | 9 (2.7) | 11 (2.6) | 0.94 (0.38‐2.30) | 1.000 | 0.98 (0.45‐2.41) | 1.000 | |
| AG + GG | 77 (23.4) | 131 (31.2) | 0.67 (0.49‐0.94) | .021 | 0.59 (0.41‐0.92) | .019 | |
| A allele | 572 (86.9) | 698 (83.1) | 1.00 (Reference) | 1.00 (Reference) | |||
| G allele | 86 (13.1) | 142 (16.9) | 0.74 (0.55‐0.99) | .043 | 0.72 (0.51‐0.98) | .040 | |
| rs5776997 (HWE = 0.315) | ‐ ‐ | 234 (71.1) | 317 (75.5) | 1.00 (Reference) | 1.00 (Reference) | ||
| ‐ T | 80 (24.3) | 93 (22.1) | 1.17 (0.83‐1.64) | .429 | 1.26 (0.96‐1.73) | .517 | |
| TT | 15 (4.6) | 10 (2.4) | 2.03 (0.90‐4.60) | .099 | 2.11 (0.93‐4.81) | .126 | |
| ‐ T + TT | 95 (28.9) | 103 (24.5) | 1.25 (0.90‐1.73) | .183 | 1.32 (0.95‐1.89) | .231 | |
| ‐ allele | 548 (83.3) | 727 (86.5) | 1.00 (Reference) | 1.00 (Reference) | |||
| T allele | 110 (16.7) | 113 (13.5) | 1.28 (0.96‐1.70) | .107 | 1.39 (0.99‐1.83) | .198 |
CI, confidence interval; OR, odds ratio. The significant P values were shown in bold.
a
Chi‐square test for genotype distributions between cases and controls.
b
Adjusted for age, sex, smoking and drinking status in logistic regress models.