Figure 4.
Concentration–response curve for GI‐530159 on stably transfected TREK1 channels. (A) Representative example of cumulative concentration–response curve for GI‐530159 on TREK1 current stably transfected in HEK293 cells. Current was measured at 0 mV. (B) Concentration–response curve reveals EC50 of 0.9 μM for GI‐530159 (n = 6 for each concentration). Each n value represents a recording from a cell on an independent coverslip on different recording days. (C) Maximum current enhancement by GI‐530159 (n = 6) is similar to that seen for BL‐1249 (n = 7) for TREK1 currents in stably transfected HEK293 cells.