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Solution structure of cVc1.1 and sequences of cVc1.1 wild‐type and variants [C2H,C8F]cVc1.1 and [N9W]cVc1.1 used in this study. cVc1.1 is an engineered peptide in which a cyclizing linker (blue) was added to confer stability and oral activity to the analgesic peptide Vc1.1. This peptide comprises two disulfide bonds, which are shown in red. The conserved positions of the cVc1.1 variants are shown using lighter colour fonts to highlight the substituted positions.
