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. 2018 Feb 13;175(12):2384–2398. doi: 10.1111/bph.14115

Figure 5.

Figure 5

[N9W]cVc1.1 inhibits the mechanosensitivity of colonic nociceptors from healthy and CVH mice. (A) Colonic nociceptor mechanosensitivity in healthy mice is significantly reduced following application of [N9W]cVc1.1, at concentrations of 10, 100 nM and 1 μM. n = 7 afferents from N = 5 healthy mice. *P < 0.05; significantly different from control; one‐way ANOVA, with Bonferroni post hoc test. (B) [N9W]cVc1.1 inhibited CVH colonic nociceptors at concentrations of 100 nM (*P < 0.05) and 1 μM. n = 7 afferents from N = 5 CVH mice. *P < 0.05, significantly different from control; one‐way ANOVA, with Bonferroni post hoc test. (C) [N9W]cVc1.1 caused significantly more inhibition at 1 μM in CVH colonic nociceptors compared with healthy colonic nociceptors (n = 7 afferents from N = 5 healthy mice, n = 7 afferents from N = 5 CVH mice. *P < 0.05, significantly different from healthy mice; one‐way ANOVA, with Bonferroni post hoc test. (D) Healthy colonic nociceptor recording, showing action potential firing in response to a 2 g vfh probe at baseline and in the presence of [N9W]cVc1.1 (1 μM). (E) Recording of a CVH colonic nociceptor showing action potential firing in response to a 2 g vfh probe at baseline and in the presence of [N9W]cVc1.1 (1 μM).