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. 2018 Feb 13;175(12):2384–2398. doi: 10.1111/bph.14115

Figure 6.

Figure 6

Direct comparison of the inhibitory effects of the various Vc1.1 analogues on colonic nociceptors from healthy and CVH mice. (A) Overall cVc1.1 evoked the largest inhibitory effect on healthy colonic nociceptors, with Vc1.1 evoking the least amount of inhibition. The cVc1.1 analogues evoked inhibition between that of Vc1.1 and cVc1.1. Analogues inhibited colonic nociceptors from healthy mice in the following rank order cVc1.1 > [N9W]cVc1.1 > [C2H,C8F]cVc1.1 > Vc1.1. Vc1.1: n = 10 afferents from N = 5 mice; cVc1.1: n = 8 afferents from N = 5 healthy mice; [C2H,C8F]cVc1.1: n = 8 afferents from N = 5 healthy mice, [N9W]cVC1.1: n = 7 afferents from N = 5 healthy mice. Analysis represents a total of 33 afferents from N = 20 healthy mice. *P < 0.05, cVc1.1 significantly different from Vc1.1; † P < 0.05, cVc1.1 significantly different from [C2H,C8F]cVc1.1; two‐way ANOVA with Bonferroni post hoc test. (B) Colonic nociceptors from CVH mice displayed the greatest degree of inhibition in the presence of cVc12.1, with Vc1.1 causing the least amount of inhibition. Analogues inhibited colonic nociceptors from CVH mice in the following rank order cVc1.1 > [N9W]cVc1.1 > [C2H,C8F]cVc1.1 > Vc1.1. Vc1.1: n = 10 afferents from N = 5 CVH mice; cVc1.1: n = 10 afferents from N = 5 CVH mice; [C2H,C8F]cVc1.1: n = 9 afferents from N = 5 CVH mice, [N9W]cVC1.1: n = 7 afferents from N = 5 CVH mice. Analysis represents a total of 36 afferents from N = 20 CVH mice. *P < 0.05, cVc1.1 significantly different from Vc1.1; two‐way ANOVA with Bonferroni post hoc test.