Table 3.
Toxicities in patients with locoregionally recurrent, metastatic, or secondary lung tumors re‐irradiated with carbon‐ion radiotherapy
| Toxicity | Grade | |||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | All | |
| Acute, n (%) | ||||||
| Dermatitis | 59 (62.1) | 5 (5.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 64 (67.4) |
| Pneumonitis | 22 (23.2) | 1 (1.0) | 0 (0.0) | 1 (1.0) | 0 (0.0) | 24 (25.3) |
| Esophagitis | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.0) |
| Rib fracture | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.0) |
| Chest wall pain | 0 (0.0) | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.0) |
| Nervous disorder | 0 (0.0) | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.0) |
| Late, n (%) | ||||||
| Pneumonitis | 15 (15.8) | 2 (2.1) | 1 (1.0) | 0 (0.0) | 0 (0.0) | 18 (18.9) |
| Rib fracture | 4 (4.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (4.2) |
| Chest wall pain | 5 (5.3) | 5 (5.3) | 1 (1.0) | 0 (0.0) | 0 (0.0) | 11 (11.6) |
| Nervous disorder | 1 (1.0) | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (2.1) |
| Pneumothorax | 1 (1.0) | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (2.1) |
| Tracheal fistula | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.0) | 1 (1.0) |
| Pleural effusion | 1 (1.0) | 3 (3.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (4.2) |
Toxicities graded according to the NCI's Common Terminology Criteria for Adverse Events (version 4.0).