Figure 6.

Candidate target gene expressions after long non‐coding RNA (lncRNA) RP11‐552M11.4 mimic and inhibitor plasmid transfection into SKOV3 cells. A, BRCA2 mRNA and (F,K) protein expressions were both observed to be decreased in the lncRNA RP11‐552M11.4(+) group compared with the NC1(+) group, whereas they increased in the lncRNA RP11‐552M11.4(−) group compared with the NC2(−) group. D, MDM2 mRNA expression was found to be decreased in the lncRNA RP11‐552M11.4(−) group compared with the NC2(−) group, whereas (I,K) no difference of protein expression was discovered. No difference of mRNA or protein expression was found in (B,G,K) MMP9, (C,H,K) TGFB1, or (E,J,K) BRAF between lncRNA RP11‐552M11.4(+) and NC1(+) groups, nor between lncRNA RP11‐552M11.4(−) and NC2(−) groups. Comparison was determined by t test. *P < .05. NS, not significant