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. 2018 Mar 15;7(6):468–476. doi: 10.1002/sctm.17-0189

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© 2018 The Authors stemcellstranslationalmedicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Efficacy of CD11a/EPCR combination post‐irradiation injury. (A): Expression of Sca‐1 and Kit on Ter119– CD27+ BM cells in nonirradiated controls (top) compared with 48 hours after 6 Gy irradiation (bottom). Percentages of KLS cells are shown. (B): Expression of HSC markers on Ter119– CD11a– EPCR+ without (0 Gy; n = 3) and with (6 Gy; n = 5) irradiation‐induced BM injury. Numbers shown are percentages of cells within CD11a– EPCR+ gate ± SD. Boxed plots show Ter119– CD11a– EPCR+ gated cells (black) and total Ter119– cells (blue). Gates (red) show phenotypic HSCs and what percentage of Ter119– CD11a– EPCR+ cells fall within those gates. Abbreviation: EPCR, endothelial protein C receptor.