Table 3.
Matches of the identified CDR3 regions with other entities. For each case, the first row represents the match identified in the IMGT/LIGM-DB or in the database available to the groups involved in the study and the second row corresponds to the MBL or CLL case from the studied cohort. ND: not detected. #Subsets definitions can be found in the study by Agathangelidis et al5.
| Match | ID | Entity/Condition | TRBV gene | TRBD gene | TRBJ gene | CDR3 amino acid sequence | CDR3 identity |
|---|---|---|---|---|---|---|---|
| 1 | P11840 | CLL patient subset #2# | TRBV12-3 | TRBD2 | TRBJ1-5 | ASSPNYSNQPQH | 100% |
| #6 | MBL | ND | |||||
| 2 | AM041151 | Epstein-Barr virus | TRBV10-3 | TRBD1 | TRBJ1-5 | AISTGDSNQPQH | 100% |
| #27 | CLL | ||||||
| 3 | HM568209 | Hepatitis C virus | TRBV10-3 | TRBD1 | TRBJ1-5 | AISESTVGNQPQH | 100% |
| #1 | MBL | ||||||
| 4 | P934 | T cell large granular lymphocyte leukemia | TRBV19 | TRBD1 | TRBJ1-5 | ASSPRGSNQPQH | 100% |
| #1 | MBL | TRBV6-6 | TRBD2 | ||||
| 5 | AF043185 | Early arthritis | TRBV12-3 | TRBD2 | TRBJ1-5 | ASTPNYSNQPQH | 100% |
| #1 | MBL | ||||||
| 6 | S48146 | Immunodeficiency | TRBV28 | TRBD2 | TRBJ2-7 | ASSLGLHYEQY | 100% |
| #27 | CLL | TRBD1 | |||||
| 7 | AY006257 | Organ post-transplantation | TRBV5-1 | TRBD1 | TRBJ1-2 | ASSLSGNYGYT | 100% |
| #4 | MBL | TRBV27 | |||||
| 8 | AY006145 | Organ post-transplantation | TRBV28 | TRBD2 | TRBJ2-2 | ASSLTSAAGELF | 100% |
| #27 | CLL | ||||||
| 9 | AM041177 | Structural limits | TRBV10-3 | TRBD1 | TRBJ1-5 | AISTGDSNQPQH | 100% |
| #27 | CLL | ||||||
| 10 | EF592018 | Herpes simplex virus-2 | TRBV27 | TRBD1 | TRBJ1-4 | ASRPQGANEKLF | 91,6% |
| #4 | MBL | TRBV7-9 | ASRPQGPNEKLF | ||||
| 11 | AJ405752 | Multiple sclerosis | TRBV27 | TRBD2 | TRBJ1-5 | ASSYEGSAQPQH | 91,6% |
| #27 | CLL | TRBV6-2 or 6-3 | TRBD1 | ASSYEGSNQPQH | |||
| 12 | CR1 | Cervical intraepithelial neoplasia | TRBV10-3 | TRBD1 | TRBJ1-5 | AISTGDVNQPQH | 91,6% |
| #27 | CLL | AISTGDSNQPQH |