Figure 6.

Changes in phosphorylated (phospho‐)MEK1/2 and phospho‐ERK1/2 have little effect on stomatin‐like protein 2 (SLP‐2) in cisplatin‐induced apoptosis in cervical cancer cell lines. A, B, a, b, HELA cells (A, B) and SIHA cells (a, b) were treated with different concentrations of U0126 (0, 2.5, 5, 10, or 15 μmol/L) for 24 h and expression of p‐MEK1/2 and p‐ERK1/2 was detected by Western blot analysis. C, D, c, d, HELA cells (C, D) and SIHA cells (c, d) were treated with 15 μmol/L U0126 for 24 h and then treated with IC ₅₀ cisplatin for 24 h and the expression of p‐MEK1/2, p‐ERK1/2, and SLP‐2 was detected by Western blot analysis. *P < .05