Figure 7.

Generation of CD4⁽⁺⁾CD39⁽⁺⁾ T cells by co‐incubation of primary CD4⁽⁺⁾ T cells with CD3⁽⁺⁾ exosomes. (a) Representative density plots showing % CD4⁽⁺⁾CD39⁽⁺⁾ T cells in co‐cultures of CD4⁽⁺⁾ T cells with exosomes carrying high or low levels of inhibitory proteins. (b) Box‐plots show increased conversion of conventional CD4⁽⁺⁾ T cells to CD39⁽⁺⁾ T cells upon co‐incubation with CD3⁽⁺⁾ exosomes carrying high or low levels of inhibitory proteins; *P < 0·05; **P < 0·005. [Colour figure can be viewed at http://wileyonlinelibrary.com]